Abstract
This is an in vitro laboratory study. It was done in order to prove the competitive inhibition between interferon-gamma (IFN-gamma) and erythropoietin (EPO) in chronic renal failure (CRF) by fixing an inhibition elicited by EPO on IFN-gamma expression by mononuclear cells. These cells were already separated from fresh anticoaggulated blood specimens from nine CRF-patients and nine healthy persons.Then, were co incubated separately with mitogen, phytohemaggluttinin with and without EPO under standard incubation conditions. Thereafter, IFN-gamma level was measured by ELISA. Results have shown that EPO significantly inhibits IFNgamma expression by mononuclear cells in healthy persons, p value < 0.05, while this inhibition is not significant in CRF-patients.
Article Type
Article
Recommended Citation
M. Jasim, Ali; A. Sultan, Baqur; and T. Mashkour, Kareem
(2026)
"Competitive Inhibition Relationship Between Erythropoietin And Interferon-Gamma In Renal Failure Anemia.,"
Al-Qadisiyah Medical Journal: Vol. 5:
Iss.
8, Article 1.
DOI: 10.28922/qmj.2009.5.8.1-7
Available at:
https://qmj.researchcommons.org/journal/vol5/iss8/1
First Page
1
Last Page
7
Rights
Copyright (c) 2017 AL-QADISIYAH MEDICAL JOURNAL
